U1131 Team 2

Team 2 is directed by Robin Fahraeus (DR Inserm)

The team has three main axis of research. One is on the role of MDM2 in controlling oncogenic and tumour suppressor pathways via binding to different mRNAs and stimulate their synthesis, including p53, or to the encoded proteins and promote their degradation, depending on cellular conditions. Another project is aimed at understanding the unique cis-acting mechanisms of mRNA translation control utilized by the Epstein-Barr virus (EBV)-encoded EBNA1 in order to develop treatments against EBV-associated cancers. The third project is focused on understanding a non-canonical mRNA translation event producing peptide substrates for the major histocompatibility class I pathway.

References

Gnanasundram SV, Pyndiah S, Daskalogianni C, Armfield K, Nylander K, Wilson JB, Fåhraeus R. PI3Kδ activates E2F1 synthesis in response to mRNA translation stress. Nat Commun. 2017 Dec 13;8(1):2103. PMID: 29235459

Mlynarczyk C and Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21 (CDKN1A). Nat Commun. 2014 Oct 8;5:5067. PMID: 25295585

Gajjar M, Candeias MM, Malbert-Colas L, Mazars A, Fujita J, Olivares-Illana V, Fåhraeus R. The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell. 2012 Jan 17;21(1):25-35. PMID: 22264786

Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S, Fåhraeus R. Endoplasmic reticulum stress induces G2 cell cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell. 2010 Apr 9;38(1):78-88. PMID: 20385091

Yin, Y., Manoury, B. and Fåhraeus, R. Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science. 2003 Sep 5;301(5638):1371-4. PMID: 12958359